Publications

* equal contribution

2009

Pahnke J, Walker L, Scheffler K, Krohn M (2009): Alzheimer's disease and blood-brain barrier function - Why have anti-beta-amyloid therapies failed to prevent dementia progression? NeurosciBiobehavR 33: 1099-1108 — PDF incl corrected Table1

Pahnke J, Krohn M, Scheffler K (2009): Die Funktion der Blut-Hirn-Schranke für die Pathogenese der Alzheimer Demenz – Implikationen für immunologische Therapien zur Plaqueauflösung. Fortschr Neurol Psyc 77: S21-24. PDF

Baumann F, Pahnke J, Radovanovic I, Rülicke T, Bremer J, Tolnay M, Aguzzi A (2009): Functionally relevant domains of the prion protein identified in vivo. PLOSone Sep 7;4(9):e6707 LINK

Lehmitz R & Pahnke J (2009): Involvement of CNS in leukaemia and lymphomas – CSF meningeosis and immunocytochemical phenotyping. Fortschr Neurol Psyc 77: S37-38. PDF

Alla V, Engelmann D, Niemetz A, Pahnke J, Schmidt A, Kunz M, Emmrich S, Steder M, Koczan D, Pützer BM (2009). E2F1 Determines Human Melanoma Progression and Metastasis via EGF Receptor Signaling. J Natl Cancer I (in press)

Soehn AS, Franck Th, Biskup S, Giaime E, Melle Chr, Rott R, Cebo D, Kalbacher H, Ott E, Pahnke J, Meitinger J, Krüger R, Gasser T; Berg D; von EggelingF, Engelender S, Alves da Costa C, Riess O (2009): Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson’s disease. Neurogenetics (in press) LINK

Westman E, Spenger Ch, Öberg J, Reyer H, Pahnke J, Wahlund LO (2009): In vivo 1H-magnetic resonance spectroscopy can detect metabolic changes in APP/PS1 mice after donepezil treatment. BMC Neuroscience 10 (33), 1-14 . PMID: 19351388

Engelmann D, Koczan D, Ricken P, Rimpler U, Pahnke J, Li Z, Pützer B (2009): Transcriptome analysis in mouse tumors induced by RET-MEN2/FMTC mutations reveals subtype-specific role in survival and interference with immune surveillance. Endocr Relat Cancer 16, 211-224. PMID: 18984779

2000-2008

Pahnke J, Wolkenhauer O, Krohn M, and Walker LC (2008): Clinico-pathologic function of cerebral ABC transporters – implications for the pathogenesis of Alzheimer’s disease. Curr Alz Research 5 (4), 396-404. PMID: 18690837 PDF HERE

Miksch RM, Armbrust S, Pahnke J, and Fusch C (2008). Outcome of very low birthweight infants after introducing a new standard regime with the early use of nasal CPAP. Eur J Pediatr 167 (8):909-916. PMID: 18172681

Hoffrogge, R., Beyer, S., Hubner, R., Mikkat, S., Mix, E., Scharf, C., Schmitz, U., Pauleweit, S., Berth, M., Zubrzycki, I. Z., Christoph, H., Pahnke J, Wolkenhauer, O., Uhrmacher, A., Volker, U., and Rolfs, A. (2007). 2-DE profiling of GDNF overexpression-related proteome changes in differentiating ST14A rat progenitor cells. Proteomics 7, 33-46. PMID: 17146836

Baumann, F., Tolnay, M., Brabeck, C., Pahnke J, Kloz, U., Niemann, H. H., Heikenwalder, M., Rulicke, T., Burkle, A., and Aguzzi, A. (2007). Lethal recessive myelin toxicity of prion protein lacking its central domain. Embo J 26, 538-47. PMID: 17245436

Henning, J., Koczan, D., Glass, A., Karopka, T., Pahnke J, Rolfs, A., Benecke, R., and Gimsa, U. (2007). Deep brain stimulation in a rat model modulates TH, CaMKIIa and Homer1 gene expression. Eur J Neurosci 25, 239-50. PMID: 17241285

Bramkamp, M., Dedes, K. J., Strobel, K., Pahnke J, Breitenstein, S., and Clavien, P. A. (2007). Cholestasis from malignant melanoma. J Clin Oncol 25, 725-6. PMID: 17308277

Marx, F. P., Soehn, A. S., Berg, D., Melle, C., Schiesling, C., Lang, M., Kautzmann, S., Strauss, K. M., Franck, T., Engelender, S., Pahnke J, Dawson, S., von Eggeling, F., Schulz, J. B., Riess, O., and Kruger, R. (2007). The proteasomal subunit S6 ATPase is a novel synphilin-1 interacting protein--implications for Parkinson's disease. Faseb J 21, 1759-67. PMID: 17327361

Wyss, M. T., Spaeth, N., Biollaz, G., Pahnke J, Alessi, P., Trachsel, E., Treyer, V., Weber, B., Neri, D., and Buck, A. (2007). Uptake of 18F-Fluorocholine, 18F-FET, and 18F-FDG in C6 Gliomas and Correlation with 131I-SIP(L19), a Marker of Angiogenesis. J Nucl Med 48, 608-14. PMID: 17401099

Spaeth, N., Wyss, M. T., Pahnke J, Biollaz, G., Lutz, A., Goepfert, K., Westera, G., Treyer, V., Weber, B., and Buck, A. (2006). Uptake of (18)F-fluorocholine, (18)F-fluoro-ethyl-L: -tyrosine and (18)F-fluoro-2-deoxyglucose in F98 gliomas in the rat. Eur J Nucl Med Mol Imaging 33, 661-5. PMID: 16538503

Hoffrogge, R., Mikkat, S., Scharf, C., Beyer, S., Christoph, H., Pahnke J, Mix, E., Berth, M., Uhrmacher, A., Zubrzycki, I. Z., Miljan, E., Volker, U., and Rolfs, A. (2006). 2-DE proteome analysis of a proliferating and differentiating human neuronal stem cell line (ReNcell VM). Proteomics 6, 1833-47. PMID: 16475233

Vogler, S., Pahnke J, Rousset, S., Ricquier, D., Moch, H., Miroux, B., and Ibrahim, S. M. (2006). Uncoupling Protein 2 Has Protective Function during Experimental Autoimmune Encephalomyelitis. Am J Pathol 168, 1570-5. PMID: 16651623

Spaeth, N., Wyss, M. T., Pahnke J, Biollaz, G., Trachsel, E., Drandarov, K., Treyer, V., Weber, B., Neri, D., and Buck, A. (2006). Radioimmunotherapy targeting the extra domain B of fibronectin in C6 rat gliomas: a preliminary study about the therapeutic efficacy of iodine-131-labeled SIP(L19). Nucl Med Biol 33, 661-6. PMID: 16843841

Zettl, U. K., Hartung, H. P., Pahnke, A., Brueck, W., Benecke, R., and Pahnke J (2006). Lesion pathology predicts response to plasma exchange in secondary progressive MS. Neurology 67, 1515-6. PMID: 17060593

Mix, E., Ibrahim, S. M., Pahnke J, Glass, A., Mazon-Pelaez, I., Lemcke, S., Koczan, D., Gimsa, U., Bansemer, S., Scheel, T., Karopka, T., Bottcher, T., Muller, J., Dazert, E., Antipova, V., Hoffrogge, R., Wree, A., Zschiesche, M., Strauss, U., Kundt, G., Warzok, R., Gierl, L., and Rolfs, A. (2006). 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor Atorvastatin mediated effects depend on the activation status of target cells in PLP-EAE. J Autoimmun 27, 251-65. PMID: 17085013

Pelaez, I. M., Vogler, S., Strauss, U., Wernhoff, P., Pahnke J, Brockmann, G., Moch, H., Thiesen, H. J., Rolfs, A., and Ibrahim, S. M. (2005). Identification of quantitative trait loci controlling cortical motor evoked potentials in experimental autoimmune encephalomyelitis: Correlation with incidence, onset and severity of disease. Hum Mol Genet 14, 1977-89. PMID: 15917267

Moeller, S., Mix, E., Blueggel, M., Serrano-Fernandez, P., Koczan, D., Kotsikoris, V., Kunz, M., Watson, M., Pahnke J, Illges, H., Kreutzer, M., Mikkat, S., Thiesen, H. J., Glocker, M. O., Zettl, U. K., and Ibrahim, S. M. (2005). Collection of soluble variants of membrane proteins for transcriptomics and proteomics. In Silico Biol 5, 295-311. PMID: 15984938

Rolfs, A., Bottcher, T., Zschiesche, M., Morris, P., Winchester, B., Bauer, P., Walter, U., Mix, E., Lohr, M., Harzer, K., Strauss, U., Pahnke J, Grossmann, A., and Benecke, R. (2005). Prevalence of Fabry disease in patients with cryptogenic stroke: a prospective study. Lancet 366, 1794-6. PMID: 16298216

Strauss, U., Kole, M. H., Brauer, A. U., Pahnke J, Bajorat, R., Rolfs, A., Nitsch, R., and Deisz, R. A. (2004). An impaired neocortical Ih is associated with enhanced excitability and absence epilepsy. Eur J Neurosci 19, 3048-58. PMID: 15182313

Pahnke J*, Mix, E.*, Ibrahim, S.*, Koczan, D., Sina, C., Bottcher, T., Thiesen, H. J., and Rolfs, A. (2004). Gene-expression profiling of the early stages of MOG-induced EAE proves EAE-resistance as an active process. J Neuroimmunol 151, 158-70. PMID: 15145614

Vogelgesang, S., Kunert-Keil, C., Cascorbi, I., Mosyagin, I., Schroder, E., Runge, U., Jedlitschky, G., Kroemer, H. K., Oertel, J., Gaab, M. R., Pahnke J, Walker, L. C., and Warzok, R. W. (2004). Expression of multidrug transporters in dysembryoplastic neuroepithelial tumors causing intractable epilepsy. Clin Neuropathol 23, 223-31. PMID: 15581025

Hochstrasser, H., Bauer, P., Walter, U., Behnke, S., Spiegel, J., Csoti, I., Zeiler, B., Bornemann, A., Pahnke, J., Becker, G., Riess, O., and Berg, D. (2004). Ceruloplasmin gene variations and substantia nigra hyperechogenicity in Parkinson disease. Neurology 63, 1912-7. PMID: 15557511

Spaeth, N., Wyss, M. T., Weber, B., Scheidegger, S., Lutz, A., Verwey, J., Radovanovic, I., Pahnke J, Wild, D., Westera, G., Weishaupt, D., Hermann, D. M., Kaser-Hotz, B., Aguzzi, A., and Buck, A. (2004). Uptake of 18F-fluorocholine, 18F-fluoroethyl-L-tyrosine, and 18F-FDG in acute cerebral radiation injury in the rat: implications for separation of radiation necrosis from tumor recurrence. J Nucl Med 45, 1931-8. PMID: 15534065

Peters, S., Mix, E., Bauer, P., Weinelt, S., Schubert, B., Knoblich, R., Bottcher, T., Strauss, U., Pahnke J, Cattaneo, E., Wree, A., and Rolfs, A. (2004). Wnt-5a expression in the rat neuronal progenitor cell line ST14A. Exp Brain Res 158, 189-95. PMID: 15309358

Pahnke J, Mix, E., Knoblich, R., Muller, J., Zschiesche, M., Schubert, B., Koczan, D., Bauer, P., Bottcher, T., Thiesen, H. J., Lazarov, L., Wree, A., and Rolfs, A. (2004). Overexpression of glial cell line-derived neurotrophic factor induces genes regulating migration and differentiation of neuronal progenitor cells. Exp Cell Res 297, 484-94. PMID: 15212950

Vogelgesang, S., Warzok, R. W., Cascorbi, I., Kunert-Keil, C., Schroeder, E., Kroemer, H. K., Siegmund, W., Walker, L. C., and Pahnke J (2004). The role of P-glycoprotein in cerebral amyloid angiopathy; implications for the early pathogenesis of Alzheimer's disease. Curr Alzheimer Res 1, 121-5. PMID: 15975076

Fischer, G., Ibrahim, S. M., Brockmann, G. A., Pahnke J, Bartocci, E., Thiesen, H. J., Serrano-Fernandez, P., and Moller, S. (2003). Expressionview: visualization of quantitative trait loci and gene-expression data in Ensembl. Genome Biol 4, R77. PMID: 14611663

Jung, H. H., Hergersberg, M., Vogt, M., Pahnke J, Treyer, V., Rothlisberger, B., Kollias, S. S., Russo, D., and Frey, B. M. (2003). McLeod phenotype associated with a XK missense mutation without hematologic, neuromuscular, or cerebral involvement. Transfusion 43, 928-38. PMID: 12823753

Bottcher, T., Mix, E., Koczan, D., Bauer, P., Pahnke J, Peters, S., Weinelt, S., Knoblich, R., Strauss, U., Cattaneo, E., Thiesen, H. J., and Rolfs, A. (2003). Gene expression profiling of ciliary neurotrophic factor-overexpressing rat striatal progenitor cells (ST14A) indicates improved stress response during the early stage of differentiation. J Neurosci Res 73, 42-53. PMID: 12815707

Pahnke J, Walker, L. C., Schroeder, E., Vogelgesang, S., Stausske, D., Walther, R., and Warzok, R. W. (2003). Cerebral beta-amyloid deposition is augmented by the -491AA promoter polymorphism in non-demented elderly individuals bearing the apolipoprotein E epsilon4 allele. Acta Neuropathol (Berl) 105, 25-9. PMID: 12471457

Pahnke J*, Mix, E.*, and Ibrahim, S. M. (2002). Gene-expression profiling of experimental autoimmune encephalomyelitis. Neurochem Res 27, 1157-63. PMID: 12462414

Vogelgesang, S., Cascorbi, I., Schroeder, E., Pahnke J, Kroemer, H. K., Siegmund, W., Kunert-Keil, C., Walker, L. C., and Warzok, R. W. (2002). Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans. Pharmacogenetics 12, 535-41. PMID: 12360104

Vogelgesang, S., Schroeder, E., Walker, L. C., Pahnke J, Naubereit, A., Walther, R., Stausske, D., and Warzok, R. W. (2002). Activated microglia do not mediate the early deposition of Abeta in carriers of the apolipoprotein Eepsilon4 allele. Clin Neuropathol 21, 99-106. PMID: 12049183

Vogelgesang, S., Junge, M. H., Pahnke J, Gaab, M. R., and Warzok, R. W. (2002). August 2001: Sellar/suprasellar mass in a 59-year-old woman. Brain Pathol 12, 135-6, 9. PMID: 11770897

Bauer, P., Knoblich, R., Mix, E., Pahnke J, and Rolfs, A. (2002). Transplantation in neurodegenerative diseases - recent advances and perspectives. Nervenheilkunde 21, 88-93. ISI:000174680500007

Korenkov, A. I., Pahnke J, Frei, K., Warzok, R., Schroeder, H. W., Frick, R., Muljana, L., Piek, J., Yonekawa, Y., and Gaab, M. R. (2000). Treatment with nimodipine or mannitol reduces programmed cell death and infarct size following focal cerebral ischemia. Neurosurg Rev 23, 145-50. PMID: 11086739

Walker, L. C.*, Pahnke J*, Madauss, M., Vogelgesang, S., Pahnke, A., Herbst, E. W., Stausske, D., Walther, R., Kessler, C., and Warzok, R. W. (2000). Apolipoprotein E4 promotes the early deposition of Abeta42 and then Abeta40 in the elderly. Acta Neuropathol (Berl) 100, 36-42. PMID: 10912918